Antisperm antibodies are one immune factor which could be involved in infertility. Antisperm antibodies are cells that fight against normal, healthy sperm. If you have anti-sperm antibodies, instead of seeing sperm as natural cells, your immune system fights against your sperm and destroys them. This prevents you from producing any viable sperm. Though still to be proven, there is evidence that antibodies against sperm can result in male infertility.
Antisperm Antibodies Test:
The role of anti-sperm antibodies in causing male infertility is controversial, since no one is sure how common or how serious this problem is. However, some men (or their wives) will possess antibodies against the, which immobilize or kill them and prevent them from swimming up towards the egg. The presence of these antibodies can be tested in the blood of both partners, in the cervical mucus, and in the seminal fluid. However, there is little correlation between circulating antibodies (in the blood) and sperm-bound antibodies (in the semen).
The presence of AB should be suspected in men have a history of Vasovasostomy and vasectomy reversal or other testicular surgery or injuries and when severe Asthenospermia or spontaneous sperm agglutination is observed during routine Semen Examination. Poor sperm penetration in PCT post-coital test with normal cervical mucus cross penetration test will help to find out presence of antibodies in the sperm or cervical mucus.
Immune factor covers 10 to 15 % of male infertility as a causative factor, these include the patients in which all seminal parameters are normal but the PCT Post Coital test are poor and there is defective sperm motility also semen shows high level of sperm agglutination. In a couple with Unexplained Infertility as well as when the man having history of vasectomy reversal must be testing of AB Antisperm Antibodies.
Antisperm Antibody AB test:
It’s very important to find out that whether actual antibodies are present on the sperm itself (over tail, overhead) rather than circulating in blood.
The presence of both IgG and IgA anti-sperm antibodies are measured on the sperm surface. The results are given in terms of the number of motile sperm affected by anti-sperm antibodies surface antibodies may affect both movement of the sperm and the ability of the sperm to bind to the oocyte results are clinically significant and positive if more than 50% of sperm are affected by either class of antibody. IgA antibodies are considered of greater clinical significance than IgG.
How Do Antisperm Antibodies Affect Fertility?
Antisperm antibodies can really impair the function of healthy sperm. These antibodies attach to your sperm, reducing motility and making it more difficult for sperm to pass through cervical mucus. Antisperm antibodies can also force sperm to clump together, making it difficult for your sperm to fertilize an egg.
Testing for Antisperm Antibodies:
There are a variety of tests that can detect the presence of anti-sperm antibodies in the body:
►Blood Tests: Blood tests are commonly used to detect the antibody.
►Post-Coital Test: The post-coital test can detect the presence of anti-sperm antibodies in a woman’s cervical mucus.
►Sperm Testing: In men, sperm testing is the best way to analyze for anti-sperm antibodies. The immune bead assay and the mixed agglutination reaction test are both used.
Treating Antisperm Antibodies:
Conventionally there are a variety of treatments available to help couples struggling with anti-sperm antibodies to conceive. At Imran Medical Center, we follow a highly advanced Infertility treatment pool, free of steroids & hormones to offer a natural treatment to Antisperm Antibodies.
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